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Anti -SIRP alpha Rabbit pAb

價格: 在線咨詢
貨號:
KT011549
產(chǎn)品規(guī)格:
100 μL
Applications:
WB | IHC | IF
Species:
M,M
購買數(shù)量:
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Product Information


Description

SIRP alpha rabbit polyclonal antibody

Protein full name

signal-regulatory protein alpha

Synonyms

BIT, CD172A, Inhibitory receptor SHPS 1, Macrophage fusion receptor, MFR, MYD 1, MyD 1 antigen, MYD1, P84, PTPNS1, SHP substrate 1, SHPS 1, SHPS1, SIRP, SIRP alpha, SIRP ALPHA 1, SIRPA, SIRPalpha

Immunogen

Recombinant protein corresponding to Mouse SIRP alpha

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Predicted MW.

56 kDa

Observed MW.

120 kDa

Uniprot ID

P97797




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse

1: 500-1: 1000

spleen

IHC/IF

Mouse

1: 2000-1: 4000

lung




Background


Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. 




Images


Picture 1.png Western blot analysis of SIRP alpha (GB113962) at dilution of 1: 1000
Picture 2.png Immunohistochemistry of paraffin embedded mouse lung using SIRP alpha (GB113962) at dilution of 1: 2000 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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